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Retraction: Monocyte Tissue Factor Induction by Activation of ₂-Glycoprotein-I-Specific T Lymphocytes Is Associated with Thrombosis and Fetal Loss in Patients with Antiphospholipid Antibodies

We wish to withdraw the results of the paper by Sudha Visvanathan, Carolyn L. Geczy, Jason A. Harmer, and H. Patrick McNeil, "Monocyte Tissue Factor Induction by Activation of ₂-Glycoprotein-I-Specific T Lymphocytes Is Associated with Thrombosis and Fetal Loss in Patients with Antiphospholipid Antibodies," The Journal of Immunology 2000;165:2258–2262. The first author of the original manuscript, Sudha Visvanathan, has declined to sign the correction letter.

In the above article, we reported that blood mononuclear cells from patients with the antiphospholipid syndrome (APS) expressed high levels of tissue factor (TF) when stimulated with plasma-purified ₂-glycoprotein-I (₂GPI) in vitro, whereas little or no TF was induced when blood from patients without the APS or healthy controls was tested. Subsequent experiments using recombinant ₂GPI and a range of different preparations of purified ₂GPI have shown much more variable and less consistent results than those we reported. After extensive testing, we feel that differences are unlikely to be due to contaminating endotoxin in some of the preparations. Although an explanation for the discrepancy remains unclear, we can no longer conclude that ₂GPI is the cause of the observed TF induced on mononuclear cells from patients with APS, and for this reason, we wish to withdraw the results reported in this manuscript.

H. Patrick McNeil

Inflammation Research Unit

School of Medical Sciences

University of New South Wales

Sydney, Australia

Carolyn L. Geczy

Jason A. Harmer

Cytokine Research Unit

School of Medical Sciences

University of New South Wales

Sydney, Australia

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McNeil, H. P. Articles by Harmer, J. A. Search for Related Content PubMed PubMed Citation Articles by McNeil, H. P. Articles by Harmer, J. A.