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Erratum for Wiszniewski et al., J Immunol 167 (3) 1787-1794.
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The Journal of Immunology, 2002, 169: 607.
Copyright © 2002 by The American Association of Immunologists

Mutation in the Class II trans-Activator Leading to a Mild Immunodeficiency

Wojciech Wiszniewski, Marie-Claude Fondaneche, Françoise Le Deist, Maria Kanariou, Françoise Selz, Nicole Brousse, Viktor Steimle, Giovanna Barbieri, Catherine Alcaide-Loridan, Dominique Charron, Alain Fischer and Barbara Lisowska-Grospierre


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Wojciech Wiszniewski, Marie-Claude Fondaneche, Françoise Le Deist, Maria Kanariou, Françoise Selz, Nicole Brousse, Viktor Steimle, Giovanna Barbieri, Catherine Alcaide-Loridan, Dominique Charron, Alain Fischer, and Barbara Lisowska-Grospierre. Mutation in the Class II trans-Activator Leading to a Mild Immunodeficiency. The Journal of Immunology 2001;167:1787–1794.

The authors found in Figure 5 that wild-type EGFP-CIITA had been used inadvertently for immunofluorescence localization instead of the L469P mutant. They found the bona fide CIITA-L469P is localized predominantly in the cytoplasm; however, it also transits through the nucleus since it shows strong nuclear accumulation after leptomycin treatment. Residual nuclear localization of CIITA-L469P is also found by biochemical analysis of the patient fibroblasts subcellular fractions and is supported by the residual transactivation potential of CIITA-L469P. The main findings and conclusions of the paper remain unchanged.





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