HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Des Prez, R. M. Search for Related Content PubMed PubMed Citation Articles by Des Prez, R. M.

The Effects of Bacterial Endotoxin on Rabbit Platelets

V. Heat Labile Plasma Factor Requirements of Endotoxin-Induced Platelet Injury¹

From the Department of Medicine, Vanderbilt University and the Veterans Administration Hospital, Nashville, Tennessee

Abstract

The heat-labile plasma factor (HLPF) necessary for endotoxin-induced platelet injury in citrated plasma has been investigated. HLPF does not appear to be complement since no complement fixation occurs during the course of the platelet-endotoxin interaction. A functionally similar factor removed from plasma by zymosan appears to be the same in substitution experiments. The conditions employed in the zymosan adsorption also differentiate the adsorbed factor from complement. The relationship of this factor to properdin is discussed.

Footnotes

This investigation was supported by Research Grants HE-08399, AI-03082, and AI-00323 from the National Institutes of Health, United States Public Health Service.