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Antigenic Variants of Arboviruses

III. Host Passage Selection of Constituent Antigen Subpopulations of Strains¹

From the Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut

Abstract

1. When EE or WE virus strains were serially passaged in tissue culture, constituent antigen properties were expressed at the specific passage level when there occurred an equilibrium in subpopulation antigens. The equilibrium could be recognized only under defined conditions of host passage and was measured by specifically designed serologic techniques.

2. WE virus strains were found to comprise two groups, each with distinct constituent antigen properties.

3. EE virus strains comprised four groups, each with distinct constituent antigen properties.

4. Certain South American type EE strains had constituent antigen properties identical to certain North American type EE strains.

Footnotes

This study was conducted under the auspices of the Commission on Viral Infections of the Armed Forces Epidemiological Board and was supported in part by the Office of the Surgeon General, Department of the Army, in part by United States Public Health Service Grant AI 04566 from the National Institute of Allergy and Infectious Diseases, and in part by a contract from the United States Army Biological Laboratories, Fort Detrick, Maryland.

² United States Public Health Service Postdoctoral Research Fellow, 1965. Present address: Department Microbiology, Yale University School of Medicine, New Haven, Connecticut.