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Herpes Simplex Neutralizing Antibody—Quantitation of the Complement-Dependent Fraction in Different Phases of Adult Human Infection¹

From the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Abstract

A quantitative analysis of complement dependence in herpes antibody was carried out, using the plaque-reduction technique to test sera from young adults with primary and recurrent herpes. The results suggest the following conclusions:

Between one- and two-thirds of neutralizing antibody activity is complement dependent.

Neither the fraction of complement-dependent antibody nor the serum complement level varies in the different phases of recurrent herpes in such a manner as to suggest any role of complement in allowing or preventing recurrences.

In adult primary herpes, complement-dependent and complement-independent antibody appear together, so that complement dependence cannot be used in the diagnosis during the acute phase.

Footnotes

¹ This work was done during the tenure of a Postdoctoral Research Scholarship from the American Cancer Society.