HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Horibata, K. Articles by Uhr, J. W. Search for Related Content PubMed Articles by Horibata, K. Articles by Uhr, J. W.

Antibody Content of Single Antibody-Forming Cells¹

Irvington House Institute and Department of Medicine, New York University School of Medicine, New York, New York

Abstract

The antibody content of individual antibody-forming cells obtained from rats immunized to Salmonella flagella was studied. Antibody-forming cells from the popliteal lymph nodes were identified by the capacity of the cells to specifically adhere motile bacteria that share antigens with the flagella used for immunization. In rats immunized with flagella alone, adherence-positive cells obtained 1 week after immunization contained relatively large amounts of antibody. In immunized rats that also received specific antiserum 1 day later, adherence-positive cells obtained 1 week after immunization did not contain detectable antibody. The possible mechanisms by which passive antibody can effect the antibody content of antibody-forming cells that appear after immunization are discussed.

Footnotes

This work was supported in part by U.S. Public Health Service Grant No. AI-01821-09, by the Health Research Council of the City of New York U-1647, and by the Commission on Immunization of the Armed Forces Epidemiological Board, and supported in part by the Office of The Surgeon General, Department of the Army, Washington, D.C.

² Present address: The Salk Institute for Biological Studies, Post Office Box 1809, San Diego, California 92112.