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Canine Immunoglobulins

II. Antibody Activities in Six Immunoglobulin Classes¹

Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York

Abstract

In the present report evidence is presented for the existence of antibody activities in each of six canine immunoglobulin classes. Among nine precipitating canine antisera to hemocyanin, bovine serum albumin or rabbit thyroglobulin, antibodies were evidenced in _2a, _2b and 7S ₁-immunoglobulins by radioimmunoelectrophoresis. An electrophoretically fast migrating non-precipitating canine anti-BSA antibody previously reported by Patterson et al. was found to consist entirely of 7S ₁. Among 15 canine anti-A sera, isohemagglutinins were found which reacted with each of the specific anti-immunoglobulins. In one serum from a lupus dog, anti-nuclear antibody was demonstrated among _2a-, _2b-, 7S ₁- and M-immunoglobulins.

Footnotes

Supported by Grants AM 02443, AI 02349 and 2 T1 AI 28 from the National Institutes of Health.

² Recipient, Post-Doctoral Fellowship Award from The Arthritis Foundation. Present address: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland.

³ Recipient, Research Career Award from the National Institutes of Health.

⁴ Professor of Medicine, University of Rochester School of Medicine and Dentistry, Department of Medicine, Rochester, New York.