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Hypersensitivity to Ascaris Antigens

I. Skin-Sensitizing Activity of Serum Fractions from Guinea Pigs Sensitized to Grude Extracts¹

Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena, California

Abstract

Guinea pigs were immunized with a crude preparation of Ascaris suum extract. Their sera were separated by preparative electrophoresis in agar and the isolated fractions were tested by agar immunoelectrophoresis for the presence of 7S -1- and -2-globulins, by cellulose-acetate immunoelectrophoresis for the presence of precipitating antibodies to Ascaris antigens and by passive cutaneous anaphylaxis (PCA) in guinea pigs. The results indicated that both 7S -1 and -2 anti-Ascaris antibodies had the ability to elicit PCA reactions although more 7S -2 was necessary for a positive skin reaction to occur.

Footnotes

This investigation was supported by the National Institute of Allergy and Infectious Diseases, Grants A1-01339 and 5 T1 AI-127 (Contribution no. 3437).

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