The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1967, 98, 881 -887
Copyright © 1967 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borel, Y.
Right arrow Articles by Miescher, P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Borel, Y.
Right arrow Articles by Miescher, P.

Dissociation of Immune Responses by the Induction of Partial Unresponsiveness

Relationship of PCA and Complement-Fixing Antibody Formation to the Suppression of Delayed Hypersensitivity

Yves Borel1, Marthe Fauconnet and Peter Miescher2

Department of Medicine, New York University School of Medicine, New York, New York

Abstract

Administration of dinitrophenyl-ovalbumin to newborn guinea pigs resulted in the specific suppression of delayed hypersensitivity to this antigen after immunization with the same antigen in complete adjuvant in about half of the animals. The duration of the suppression of delayed hypersensitivity appears to be related to the dose of antigen administered in the 1st week of life.

Delayed hypersensitivity was successfully transferred with sensitized lymph node cells to recipient animals which had been rendered "partially tolerant."

Complement-fixing but not passive cutaneous anaphylaxis (PCA) antibody were also suppressed at 6 and 8 weeks of age in about half of the animals injected neonatally with a large dose of antigen.

A similar state of "partial unresponsiveness" was obtained in adult animals, although under these experimental conditions, larger amounts of antigen appear to be necessary.

No correlation was found between the suppression of delayed hypersensitivity and the formation of {gamma}1 (PCA) and complement-fixing antibody. These data support the assumption that the various immune phenomena evolve independently of each other. Some biologic implications of a state of "partial unresponsiveness" are discussed.

Footnotes

1 Postdoctoral fellow of graduate training program 2A-5282.

2 Health Research Council Career Scientist of the City of New York.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1967 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1967 by The American Association of Immunologists, Inc. All rights reserved.