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Immunochemical Properties of Fc Fragment of Rabbit G-Globulin¹

Division of Laboratories and Research, New York State Department of Health², and Department of Microbiology, Albany Medical College, ^,2 Albany, New York

Abstract

Various fractions comprising Fc fragment appear to be similar in their reactivity to horse and goat anti-rabbit G-globulin serum, as determined by immunodiffusion and quantitative immunoprecipitation techniques. These fractions show marked differences in their anti-complementary properties. These results indicate that the anti-complementary site of Fc fragment may be different from its major antigenic determinant.

Footnotes

¹ Aided by grants from the National Institutes of Health, United States Public Health Service (AI 05191), and the National Science Foundation (GB-4668). A preliminary report of this work was presented before the Federation of American Societies for Experimental Biology in April 1966, at Atlantic City, New Jersey.

² Affiliated with the Institute of Preventive Medicine.