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Isolation of Rat Lung Antigens Capable of Neutralizing Localizing Activity of Anti-Lung Antibodies¹

Department of Biochemistry Research, Roswell Park Memorial Institute, ³ Buffalo, New York

Abstract

Soluble material capable of neutralizing the localization in vivo of rabbit anti-rat lung antibodies was obtained by autolysis of the saline insoluble sediment of rat lung. The autolysate was fractionated by gel filtration into fractions which differed in the effectiveness in neutralizing the localizing activity as well as in antigenic composition as shown by immunodiffusion, indicating a multiplicity of the localizing antibodies and the corresponding antigens. The digestion of lung sediment with trypsin destroyed a major portion of lung antigens responsible for the localizing antibodies.

Footnotes

This work was supported in part by Grant No. AI-5158 from the National Institute of Allergy and Infectious Diseases.

² On leave of absence from the Department of Obstetrics and Gynecology, Osaka University Medical School, Osaka, Japan.

³ A unit of the New York State Department of Health.