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Changes in the Concentrations of the _c-Globulin and the G-Globulin of Bovine Cerebrospinal Fluid with Maturation¹

Department of Psychiatry, Allan Memorial Institute, McGill University, Montreal, Quebec, Canada

Abstract

1. The average _c-globulin concentration in bovine CSF withdrawn from newly-born colostrum-deprived calves was found to be 1.4 mg/100 ml. This level decreased sharply a few days after birth and the average value for 4-month-old animals was 0.44 mg/100 ml. The CSF of 3-year-old steers contained 0.22 mg/100 ml.

2. Pooled fetal serum contained 2.8 mg of _c-globulin/100 ml. This level dropped by one-third at birth and then remained stationary up to 4 months of age.

3. Bovine colostrum was found to have on the average 15 mg of _c-globulin/100 ml.

4. About 0.01 mg of _c-globulin/g of wet tissue was found in cerebral white matter and spinal cord from calves. The cerebellum and cerebral gray matter contained one-third this amount.

5. The G-globulin was detected in the CSF of newly-born colostrum-deprived calves by immunodiffusion techniques but not quantitated. At 4 months of age the CSF contained 1.40 mg/100 ml and at 3 years of age 2.22 mg/100 ml.

6. A small amount of autogenous G-globulin was found in both fetal serum and in the serum of newly-born colostrum-deprived calves. Two weeks after birth the concentration of this protein had increased to 50 mg/100 ml. Pooled serum from 4-month-old calves had a G-globulin content of 400 mg/100 ml.

Footnotes

This work was presented in part in July, 1965, at the International Neurochemical Conference in Oxford, England, and was supported by a grant from the Multiple Sclerosis Society of Canada.