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The X-Y-Z Scheme of Immunocyte Maturation

III. Early IgM Memory and the Nature of the Memory Cell¹

Department of Bacteriology, University of California, Los Angeles, California

Abstract

It is shown that the capacity for rapid and augmented recall of cellular IgM antibody production ("IgM memory"), in the sheep red cell system of the mouse, can be detected as early as 1 day after an initial dose of 2 x 10⁶ SRBC, and reaches a peak concomitant with the peak of the IgM response. The transitory nature of this capacity is indicated, firstly, by its eight-fold decrease 1 month after priming. Secondly, if the net excess secondary response is induced 1 day or 1 month following priming, rather than at the optimal time, the "memory" increment falls to zero quickly.

These findings have given rise to an altered view of the heterogeneity of the Y or memory cell which is discussed at length.

Footnotes

¹ This work was done under the sponsorship of National Science Foundation Grant GB-1619, and University of California at Los Angeles Cancer Research Institutional Grant 474-IN-3G.