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The Journal of Immunology, 1967, 98: 827-835.
Copyright © 1967 by The American Association of Immunologists, Inc.
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The X-Y-Z Scheme of Immunocyte Maturation

II. The Effect of Antigen on Spontaneous Escape from Immune Paralysis1

Stanley J. Dowden and Eli E. Sercarz

Department of Bacteriology, University of California, Los Angeles, California

Abstract

1. Mice receiving a total of 16 to 18 mg of bovine serum albumin (BSA) during the first 3 weeks of life, including 2 mg of alum-precipitated BSA as a last injection, displayed so-called "spontaneous escape."
2. A very small percentage of animals receiving only soluble BSA exhibited this phenomenon during the time course of these studies.
3. Spontaneous escape was delayed in animals which were challenged 1 or 2 weeks postregimen.
4. Spontaneous escape was hastened in animals which were challenged 3 or 4 weeks postregimen by means of alum-precipitated BSA.
5. After the administration of a supposedly hyperimmunizing series of injections from the 2nd to the 6th week postregimen, paralysis was prolonged with respect to onset of response and the level of antibody produced.
6. From these studies it is concluded that one important route of "spontaneous escape" involves a sequence of paralysis, the generation of memory cells, and contact of these cells with endogenously retained antigen, followed by extensive antibody formation.
7. A dualistic view of escape was supported in the discussion toward which both reversibly paralyzed X cells and virgin competent immunocytes make a contribution.

Footnotes

1 Research sponsored by the National Science Foundation (GB 1619).






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