HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ribble, J. C. Search for Related Content PubMed PubMed Citation Articles by Ribble, J. C. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB NICOTINAMIDE

A Mechanism of Bacterial Interference in vitro¹

Department of Medicine, The New York Hospital-Cornell Medical Center, New York, New York

Abstract

A strain of coagulase-negative Staphylococcus (strain W) inhibited the growth of a coagulase-positive Staphylococcus (strain 502A) when both were growing in liquid medium. Inhibition of growth was abolished by the addition of nicotinamide.

Bacteria-free filtrates of cultures of strain W failed to fully support the growth of strain 502A or the growth of several other Gram-positive bacteria. Addition of small amounts of nicotinamide or boiling restored the capacity of the filtrates to support growth.

It is postulated that the growth of strain W results in the production of an inhibitor which interferes with the metabolism of nicotinamide.

Footnotes

¹ Supported by United States Public Health Service Grants AI-06220 and TI-AI-255 and Grant U-1248 from The Health Research Council of The City of New York.

A partial report of this work was presented at the Fifty-Seventh Annual Meeting of The American Society for Clinical Investigation and was published in abstract form (Ribble, J. C., A mechanism of bacterial interference (abstr.), J. Clin. Invest., 44: 1091, 1965).

² Career Scientist of The Health Research Council of The City of New York.