HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Denman, A. M. Articles by Stastny, P. Search for Related Content PubMed Articles by Denman, A. M. Articles by Stastny, P.

Termination of Acquired Tolerance by Administration of Small Lymphocytes¹

Department of Internal Medicine (Rheumatic Diseases Unit), The University of Texas Southwestern Medical School, Dallas, Texas

Abstract

Administration of small lymphocytes obtained from the lymph nodes and spleens of normal isologous donors resulted in a restoration of the capacity for antibody production in x-irradiated, neonatally tolerant rats. Unresponsiveness of tolerant animals could be terminated with as few as 5 x 10⁶ small lymphocytes. Simultaneous injection of tolerant cells did not appear to influence this effect. Restoration of antibody production in x-irradiated rats could also be achieved with small lymphocytes from the blood, but small lymphocytes of the thymus were ineffective. The results indicate that the specific deficiency which exists in neonatal tolerance is corrected when normal small lymphocytes are given to neonatally tolerant rats. They also suggest that all other components of lymphoid tissue which may be required for the immune response retain their function in the neonatally tolerant animal.

Footnotes

Supported by Project Grant AM-09989 and Training Grant AM-05154 from the National Institute of Arthritis and Metabolic Diseases.

² Trainee in Arthritis, National Institute of Arthritis and Metabolic Diseases.