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The Relationship between Maternal Rh₀ Antibody Combining Properties and Severity of Erythroblastosis¹

Blood Center, Department of Medicine, Michael Reese Hospital and Medical Center, Chicago, Illinois

Abstract

A comparison of quantitative agglutination curves obtained with maternal Rh₀ antisera, shows a relationship between antibody-combining properties and the severity of erythroblastosis. A few exceptions were noted. Curves of greater magnitude than could be expected from the severity of the disease were found to be due to the presence of M saline-agglutinating Rh₀ antibodies. Curves weaker than expected from the severity of the disease were shown, by agglutination-inhibition, to be due to antibodies capable of producing a strong primary attachment to the red cells. A strong primary attachment would appear to be a more important antibody property in the initiation of erythroblastosis than the secondary attachment, which results in agglutination.

In general, the immune response in pregnancy was found to be less potent than that attainable by artificial immunization. The maternal antibodies produced in response to Rh₀ incompatible fetal red cells appeared to be as variable in their combining properties as those encountered in any other immune system.

Footnotes

This work was supported by Research Grant AM-09170 from the United States Public Health Service.