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The Interaction of Antigen with Leucocytes of Allergic Individuals¹

From the Allergy-Immunology Section, Department of Medicine, Northwestern University Medical School, Chicago, Illinois

Abstract

The reaction of specific antigens with leucocytes from sensitive donors has been studied. Under appropriate conditions antigen will combine with the cells at 37°C or at 4°C and in the presence or absence of Ca⁺⁺ and Mg⁺⁺ without the release of significant quantities of intracellular histamine. Washed primed cells will release their histamine upon incubation at 37°C in buffer containing Ca⁺⁺ and Mg⁺⁺ but in the absence of added antigen.

Footnotes

¹ This investigation was supported in part by Public Health Service Research Grant A106139-03 from the National Institute of Allergy and Infectious Diseases and the Ernest S. Bazley Asthmatic Research Fund, Chicago Wesley Memorial Hospital.

² Career Development Investigator Awardee, Public Health Service Research Grant No. 5-K3-19, 460-02.