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Antigenic Analysis of Tumors and Sera from Animals Inoculated with Para-Adenovirus Populations¹

From the Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas

Abstract

The oncogenicity for hamsters of a PARA-adenovirus 7 population carrying SV40 determinants was confirmed and the immunologic events studied. Tumors induced by PARA-adenovirus 7 were virus-free but synthesized SV40 tumor antigen. Almost all the animals bearing tumors induced by this virus produced antibodies against SV40 tumor antigen and 50 percent also produced antibodies against adenovirus tumor antigen.

Transcapsidation of PARA from adenovirus type 7 to adenovirus type 2 conferred oncogenic properties to the previously nontumorigenic adenovirus 2. Again, the resulting tumors were virus-free. Cells established in culture from the tumors synthesized SV40 tumor antigen. In addition, most of the animals produced antibodies against both SV40 and adenovirus tumor antigens.

Footnotes

¹ This investigation was supported in part by Public Health Service Research Grant CA-04600 from the National Cancer Institute, and grants AI-05382 and 5 T1 AI 74 from the National Institute for Allergy and Infectious Diseases, National Institutes of Health.

² American Cancer Society Professor of Virology.