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The Journal of Immunology, 1966, 97: 822-827.
Copyright © 1966 by The American Association of Immunologists, Inc.
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"Protein A" from S. Aureus

I. Pseudo-Immune Reaction with Human {gamma}-Globulin

Arne Forsgren and John Sjöquist

From the Department of Microbiology, University of Umeå, Umeå, Sweden

Abstract

Protein A was isolated from S. aureus and shown to precipitate about 45% of a pooled normal human {gamma}G preparation. In addition it was demonstrated that protein A reacts with myeloma {gamma}G-globulin, H chains from both normal and myeloma {gamma}G-globulins and the Fc fragment of normal {gamma}G-globulin. Thus, the reaction is not a true antigen-antibody reaction.




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