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The Journal of Immunology, 1966, 97: 797-804.
Copyright © 1966 by The American Association of Immunologists, Inc.
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An Immunochemical Analysis of Bacterial Mucopeptides1

Walter W. Karakawa2, Henry Lackland and Richard M. Krause

From the Department of Preventive Medicine, Washington University School of Medicine, St. Louis, Missouri

Abstract

Mucopeptides extracted from gram-positive and gram-negative bacteria which were solubilized by ultrasonic treatment gave precipitin reactions with rabbit antistreptococcal serum. A haptenic inhibitor isolated from S. albus enzymes digest of Group D streptococcal cell walls inhibited this precipitin reaction between the mucopeptides of heterologous bacteria and streptococcal antiserum. Greater than 87% inhibition of the M. lysodeikticus and 65% inhibition of the E. coli quantitative mucopeptide precipitin reactions was achieved with 4 mg/ml of this inhibitor. In double diffusion studies, the mucopeptides from different species of bacteria and streptococcal mucopeptide antiserum formed merging precipitin lines. These results suggest that the mucopeptides of many different species of bacteria possess antigenic determinants which are immunochemically similar to those of streptococci.

Footnotes

1 This study was supported in part by NIH Research Grant No. 08027, National Heart Institute, and NIH Training Grant No. 5 T1 GM 807, National Institute of General Medical Sciences. It was conducted in part under the sponsorship of the Commission on Streptococcal and Staphylococcal Diseases, Armed Forces Epidemiological Board, and was supported by the Office of the Surgeon General, Department of the Army, Washington, D. C.

2 NIH Trainee in Epidemiology.






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