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M and G Antibodies in Mice: the Response to S. Adelaide and the Effect of Splenectomy¹

From the Rockefeller University, New York, New York

Abstract

The primary antibody response to S. adelaide has been studied in mice using a flagellar immobilization assay. The change in spleen weight is bimodal with time: the first peak occurring on day 4 of the response and the second on day 10. Spleen homogenate supernatants also exhibit two distinct antibody peaks, but there is no direct correlation between the size of a spleen and its antibody content.

The primary antibody response consists of the early, transient production of M antibodies followed by the production of G antibodies. This response is quantitatively reduced by the removal of spleens from mice before antigen injection. Splenectomy does not, however, alter the proportion of M to G as compared to intact mice.

Footnotes

¹ This work is from a thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Rockefeller University. Presented in part at the Annual Meeting of the American Association of Immunologists at Chicago, April, 1964.

² Present address: Department of Bacteriology and Immunology, Harvard Medical School, Boston, Mass.