HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Toullet, F. T. Articles by Waksman, B. H. Search for Related Content PubMed PubMed Citation Articles by Toullet, F. T. Articles by Waksman, B. H.

Role of the Thymus in Tolerance

IV. Specific Tolerance to Homografts in Neonatally Thymectomized Mice Grafted with Thymus from Tolerant Donors¹

From the Department of Microbiology, Yale University, New Haven, Connecticut

Abstract

Neonatally thymectomized A mice, grafted at 3 weeks with 3-week-old isogenic thymus or injected with 100 x 10⁶ thymus cells, showed a nearly normal ability to reject CBA and C57B1/Ks skin grafts, which differ from A by a strong histocompatibility gene. When grafted with thymus or injected with thymus cells from mice tolerant to CBA, they showed a specific inability to reject CBA skin. On the basis of control experiments, it appeared that these animals had adoptive tolerance conveyed by the tolerant thymus cells and depending on thymus chimerism.

Footnotes

¹ Supported by Grants AI-06112 and AI-06455 of the National Institutes of Health.

² NATO Fellow, on leave of absence from the Centre de Recherches d'Immunopathologie de l'Association Claude Bernard, Hôpital Saint-Antoine, Paris.

This article has been cited by other articles:

				D. Y. Wu and I. Goldschneider Tolerance to Cyclosporin A-Induced Autologous Graft-Versus-Host Disease Is Mediated by a CD4+CD25+ Subset of Recent Thymic Emigrants J. Immunol., June 15, 2001; 166(12): 7158 - 7164. [Abstract] [Full Text] [PDF]

				D. Y. Wu and I. Goldschneider Cyclosporin A-Induced Autologous Graft-Versus-Host Disease: A Prototypical Model of Autoimmunity and Active (Dominant) Tolerance Coordinately Induced by Recent Thymic Emigrants J. Immunol., June 1, 1999; 162(11): 6926 - 6933. [Abstract] [Full Text] [PDF]

				S. Issazadeh, M. Zhang, M. H. Sayegh, and S. J. Khoury Acquired Thymic Tolerance: Role of CTLA4 in the Initiation and Maintenance of Tolerance in a Clinically Relevant Autoimmune Disease Model J. Immunol., January 15, 1999; 162(2): 761 - 765. [Abstract] [Full Text] [PDF]