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Blood Clearance of Enteroviruses in the Normal and Immune Rat¹

From the Unit I (Washington University) Medical Service, St. Louis City Hospital, and the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri

Abstract

The clearance of poliovirus, Types I, II and III, Coxsackie B 1 through 6 and A 9 virus was studied in normal and immune rats. Normal rats reduced the titer of injected virus from that in the inoculum by approximately 1.66 log₁₀ at 1 hr. This value was referred to as the clearance index. The clearance index at 4 days after virus injection increased to more than 5 log₁₀ and this acceleration of clearance could be detected as long as 8 months after a single virus injection, or after immunization with formalinized poliovirus vaccine. Prior injection of poliovirus Type I was followed by accelerated clearance of Type II at 1 week but not at 1 month after the first injection. The reciprocal reaction was also observed. No enhancement of clearance was noted with prior exposure to any or all of the Coxsackie B or A 9 viruses. Virus mixed with immune serum was cleared more rapidly in normal rats which then failed to develop their own capacity for increased clearance.

Footnotes

¹ These studies were supported by United States Public Health Service Research Grant AI 06632 and grants from the Institute of Medical Education and Research of the City of St. Louis.