HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Santos, G. W. Search for Related Content PubMed PubMed Citation Articles by Santos, G. W.

Adoptive Transfer of Immunologically Competent Cells

III. Comparative Ability of Allogeneic and Syngeneic Spleen Cells to Produce a Primary Antibody Response in the Cyclophosphamide Pretreated Mouse¹

From the Department of Medicine, The Johns Hopkins University, and the Oncology Service, Baltimore City Hospitals

Abstract

Adoptive transfer of a primary agglutinin response to sheep erythrocytes by spleen cells given to cyclophosphamide pretreated mice was studied. Various syngeneic, parent-to-hybrid and allogeneic donor-host combinations were investigated.

A linear log₂ relationship between the agglutinin titer measured 5 days after transfer and the dose of nucleated cells injected existed for all the combinations studied. The slopes of the regression lines obtained with the various donor-host combinations were independent of the type of transfer, but the altitudes differed. In general, the magnitude of the agglutinin response was greater in allogeneic or parent-to-hybrid transfers than in the two possible syngeneic transfers represented by each donor-host pair.

Possible reasons for this "allogeneic enhancement" are considered.

Footnotes

¹ This investigation was supported by Public Health Service Research Grants Nos. CA-06973 and 5T4CA-5091 from the National Cancer Institute.

² Leukemia Society Scholar.