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Immune Response to Polypeptides (Poly--Amino Acids) in Inbred Guinea Pigs¹

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland and the New Jersey College of Medicine and Dentistry, Microbiology Department, Jersey City, New Jersey

Abstract

1) The results obtained in guinea pigs of inbred strains 2 and 13 and the 100% immune responses obtained in F₁ hybrids of these strains are compatible with the concept that the ability to respond immunogenically against synthetic polymers is genetically controlled and is a dominant Mendelian trait.

2) Oligolysine-containing copolymers, glutamic acid-alanine (GA) and glutamic acid + methylated guinea pig plasma albumin (G+Me GPA) aggregate were found to be immunogenic for inbred strain 2 and nonimmunogenic for inbred strain 13. Copolymer glutamic acid-alanine-tyrosine (GAT) and glutamic acid-tryosine + methylated bovine plasma albumin (GT + Me BPA) aggregate were immunogenic in both inbred strains.

3) Differences between the antigenic specificity of delayed type skin reactions and PCA reactions were found in the case of GLA, GLT, GLAT copolymers in strain 2, and GAT copolymer in strain 13.

Footnotes

¹ Presented in part at the annual meeting of the American Association of Immunologists, Atlantic City, New Jersey, 1965. (Fed. Proc., 24: 181, 1965).

Paper XXII in series on antigenicity of polypeptides (Polyalpha amino acids).

² Permanent address: Israel Institute for Biological Research.

³ Supported by Grant AI-03514 from the National Institute of Allergy and Infectious Diseases (NIH).

Research Career Investigator (K6-AI-15,210), National Institute of Allergy and Infectious Diseases.

Present address: Department of Biochemistry, Jefferson Medical College, Philadelphia, Pennsylvania.

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