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Antibody Formation

V. The Avidity of M and G Guinea Pig Antibodies to Bacteriophage 174¹

From the Irvington House Institute and Department of Medicine, New York University School of Medicine, New York, New York

Abstract

Avidity of guinea pig antibodies to bacteriophage X 174 was studied by means of the decision-tube and reactivation methods of Jerne and Avegno. The avidity of both M and G antibodies increased with time after immunization. M antibody obtained 1 week after immunization usually had a higher avidity than G antibody obtained 2 weeks after immunization. The possibility that the relatively high avidity of M antibody is caused by multiple binding between a single phage particle and one M antibody molecule is discussed.

Footnotes

¹ Supported in part by U. S. Public Health Service Grant No. AI-0128-09 and by the Commission on Immunization of the Armed Forces Epidemiological Board, and supported in part by the Office of The Surgeon General, Department of the Army, Washington, D. C.