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Immunoglobulin Isoantigens (Allotypes) in the Mouse

III. Detection of Allotypic Antigens with Heterologous Antisera¹

From the Department of Genetics, Stanford University School of Medicine, Palo Alto, California

Abstract

Rabbits were immunized with either normal mouse immunoglobulins or isolated mouse myeloma proteins from BALB/c or (BALB/c x NZB)F₁ plasma cell tumors. The antisera were tested for antibodies directed to allotypic antigenic specificities by the method of inhibition of precipitation of I¹²⁵ labeled antigens.

Three G_2a and one G_2b allotypic specificities were detected with one or another of these rabbit antisera. These specificities each corresponded in mouse strain distribution with one of the allotypic specificities previously defined through the use of mouse isoantisera.

The possible nature of the allotypic sites versus the class specific antigen sites was briefly discussed and the potential usefulness of these heterologous antisera in allotypic systems noted.

Footnotes

¹ This work was supported by United States Public Health Service Research Grants GM-12075, CA-04681 and Training Grant 5TI-GM295.

² Fellow of the Helen Hay Whitney Foundation.

Present address: Department of Pathology, New York University School of Medicine, New York.

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