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Failure of Thymectomy in Newborn Guinea Pigs to Influence Contact Sensitization to Dinitrochlorobenzene¹

From the Department of Dermatology, New York University School of Medicine, and the Section of Dermatology, Manhattan Veterans Administration Hospital, New York

Abstract

No consistent differences were noted in the susceptibility of neonatally thymectomized guinea pigs to become sensitized to dinitrochlorobenzene as compared with sham-operated or nonoperated guinea pigs. The total, mononuclear and polymorphonuclear cell counts tended to be lower in the thymectomized animals than in the controls, but the differences were not always statistically significant.

The wasting described by other authors in neonatally thymectomized animals of other species was not observed.

Footnotes

¹ This study was aided by grants from the Marion B. Sulzberger Foundation and from the Syntex Corporation.