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Further Studies on the Anti-Globulin Factors in Human Serum to the Pepsin Digested Fragment of the RI Anti-RH Antibody¹

From the Department of Medicine, Medical College of Virginia, Richmond, Virginia

Abstract

Serum reactivity to erythrocytes sensitized with pepsin digested anti-Rh antibody Ripley was found to be almost universal in 795 undiluted sera. The donor Ripley himself showed a titer of 1:40 with sensitized cells. Pepsin digested globulins of negatively reacting sera showed the same degree of inhibition as pepsin digested globulins of positively reacting sera. Specific immunizations with Brucella and Vi antigens had no influence on the titer of this anti-globulin factor. Only a minimal degree of digestion of the globulin molecule is necessary to reveal the hidden determinant.

Footnotes

¹ This investigation was supported by Research Grants AM 04549, NIH 6416, and Public Health Service Training Grant T1 AM-5056-10, National Institutes of Health. This is publication #3 from the Charles W. Thomas Arthritis Fund.