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Studies on the Transfer of Human Delayed-Type Hypersensitivity

I. Partial Purification and Characterization of Two Active Components¹

From the Department of Allergy, Michael Reese Hospital and Medical Center, Chicago, Illinois

Abstract

Two fractions from tuberculin hypersensitive human white blood cells have been found capable of transferring tuberculin delayed hypersensitivity. One of these (C'-5) is a polynucleotide containing adenine, guanine and cytosine, but no uracil. The second transfer factor is contained in a larger molecular weight (A') fraction found to have G-globulin and other globulin and probably ₁ lipoprotein as well as ribose indicating RNA.

A fraction containing macroglobulin was unable to transfer delayed hypersensitivity.

Footnotes

¹ This work was supported by United States Public Health Service Grant AI-03309, the Illinois Tuberculosis Association and the Jessie Werthamer Service Club.

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