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In Vitro Studies on the Role of Collagen in the Induction of Hypersensitivity to Flea Bites¹

From the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and Allergy Research Division, Allergy Department, Kaiser Foundation Hospitals, San Francisco, California

Abstract

Acid soluble collagen and in vitro collected saliva of fleas were allowed to react at pH 3.5, 7.2 and 10.6 Whereas all the activity of saliva is dialyzable, the nondialyzable products of the reactions at both the acidic and the basic pHs had the capacity to induce hypersensitivity to flea bites in recipient guinea pigs; the product of the reaction at neutral pH was not immunogenic.

The ratio between the amounts of saliva and of collagen was shown to be important in the production of immunogenic products.

Footnotes

¹ This work was supported in part by research grant No. AI-03966 from the United States Public Health Service.