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Reovirus Infection in Suckling Mice: Immunofluorescent and Infectivity Studies¹

From the Section of Virus Research, Department of Pediatrics, the Department of Microbiology, and the Department of Medicine, University of Kansas School of Medicine, Kansas City, Kansas

Abstract

When reovirus type 1 was inoculated subcutaneously into suckling mice a generally nonfatal pantropic infection ensued. Infectious virus was recovered from most of the tissues tested from 1 hr to at least 20 days later. The greatest amounts of virus were recovered from 3 to 12 days after inoculation. Similarly, viral antigens were observed by fluorescent antibody staining in numerous tissues from 3 to 12 days after inoculation, with maximal antigenic distribution occurring from the 6th to the 9th days.

Footnotes

¹ This investigation was supported in whole by Public Health Service Research Grant No. AI 02514, from the National Institute of Allergy and Infectious Diseases.

² Present address: G. W. Hooper Foundation, University of California, c/o Institute for Medical Research, Kuala Lumpur, Malaysia.

³ Research Career Awardee, 5-K6-AI-1826, United States Public Health Service.