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Loss of Cytotoxicity of Rabbit Anti-Ehrlich Ascites Tumor Cell Antibody Following Pepsin Digestion¹

From the Department of Microbiology, Medical School, The University of Michigan, Ann Arbor, Michigan

Abstract

Pepsin digestion of cytotoxic 6.6S rabbit Ehrlich ascites tumor cell antibody produces 4.8S antibody which has lost its ability to bind hemolytic guinea pig complement and is not cytotoxic.

Footnotes

¹ Supported by Grant E-3880 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service, and by Michigan Memorial Phoenix Project #180, and presented in part at the 1963 meeting of the American Association of Immunologists (1).

² Present address: Wayne State University School of Medicine, Detroit, Michigan.

This article has been cited by other articles:

				S. Broder and F. Whitehouse Jr. lmmunologic Enhancement of Tumor Xenografts by Pepsin-Degraded Immunoglobulin Science, December 27, 1968; 162(3861): 1494 - 1495. [Abstract] [PDF]