HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Levine, S. Articles by Levine, L. Search for Related Content PubMed PubMed Citation Articles by Levine, S. Articles by Levine, L.

Hyperacute Allergic Encephalomyelitis: Adjuvant Effect of Pertussis Vaccines and Extracts¹

From the New York Medical College Center for Chronic Disease, Bird S. Coler Hospital Division, Welfare Island, New York; Parke, Davis and Company, Detroit, Michigan; and the Massachusetts Department of Public Health, Jamaica Plain, Massachusetts

Abstract

Pertussis vaccine acts as an adjuvant for development of allergic encephalomyelitis in rats, accelerating and intensifying it, and converting it to a hyperacute form. The active principle in pertussis vaccine was resistant at 56°C but labile at 80°C. It was absent from endotoxin preparations but was present in partially purified histamine sensitizing factor (HSF). It was present in vaccines and extracts in proportion to their HSF content. The active principle may be identical with HSF or closely associated with it.

Footnotes

¹ Supported by Grant 317-3 from National Multiple Sclerosis Society, and by Grants NB05727-01 and AI 04195 from the United States Public Health Service.

This article has been cited by other articles:

				S. Mattoo and J. D. Cherry Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies Clin. Microbiol. Rev., April 1, 2005; 18(2): 326 - 382. [Abstract] [Full Text] [PDF]

				P. D. Fillmore, M. Brace, S. A. Troutman, E. P. Blankenhorn, S. Diehl, M. Rincon, and C. Teuscher Genetic Analysis of the Influence of Neuroantigen-Complete Freund's Adjuvant Emulsion Structures on the Sexual Dimorphism and Susceptibility to Experimental Allergic Encephalomyelitis Am. J. Pathol., October 1, 2003; 163(4): 1623 - 1632. [Abstract] [Full Text] [PDF]

				D. Huang, J. Wang, P. Kivisakk, B. J. Rollins, and R. M. Ransohoff Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis J. Exp. Med., March 19, 2001; 193(6): 713 - 726. [Abstract] [Full Text] [PDF]