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The Specificity of the Immune Response Following Injection of Bovine Serum Albumin into Neonatal Mice¹

From the Department of Physiology, Stanford University, Stanford, California

Abstract

1. Neonatal mice were injected with 15 mg BSA and the temporal development of the immune response was followed. A biphasic response was observed.

2. The possibility that the nodes in the immune response represented the production of antibodies of different specificity was investigated by using serologically cross reacting antigens (BSA and HSA). Mice injected at birth with 12.5 mg BSA showed no anaphylaxis or ADAR at the challenge or rechallenge with HSA.

3. Mice injected at birth with BSA, challenged with BSA and rechallenged with HSA did show anaphylaxis and an elevated ADAR at the rechallenge. When mice injected with BSA at birth and challenged with HSA were rechallenged with BSA, the response to BSA was less than the response to BSA at the challenge. The specificity of the secondary response was discussed.

4. When mice injected at birth with 12.5 mg BSA were challenged and rechallenged with HSA and SSA simultaneously it was found that the response to determinants on the SSA molecule developed before the response to determinants on the HSA molecule. Thus, the response to individual antigenic determinants on a single molecule does develop separately with time following neonatal exposure to the antigen.

Footnotes

¹ This work was supported by Grant E-3733 from the U.S. Public Health Service.

² U.S.P.H.S. Predoctoral Fellow, GM 19,235-03.

³ U.S.P.H.S. Research Career Development Awardee, GM K3-5794-C5.