The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1966, 97: 306-312.
Copyright © 1966 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maurer, P. H.
Right arrow Articles by Pinchuck, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maurer, P. H.
Right arrow Articles by Pinchuck, P.

Antigenicity of Polypeptides (Poly-Alpha-Amino Acids)

XIX. Studies with Chemically Modified Polymers1

Paul H. Maurer2,3, Bernard F. Gerulat and Paul Pinchuck3

From the Department of Microbiology, New Jersey College of Medicine and Dentistry, 24 Baldwin Avenue, Jersey City, New Jersey

Abstract

Chemically modified derivatives of the copolymer of glutamic acid and lysine and/or alanine were prepared and studied for immunogenic and immunochemical properties. Deamination of G60L40 enhanced the immunogenicity for rabbits but not for guinea pigs. Modification of the carboxylate groups of G60A40 reduced considerably its immunogenicity for both species. The deaminated block GL and poly GAG of known sequence were very poor immunogens, possibly because of insufficient complexity in structure. Also, the importance of an appropriate concentration of free polyglutamate sequences for immunogenic activity has been mentioned as a possible explanation for these findings in rabbits.

Footnotes

1 This work was supported by Grants A1-03514 and 3T1-A1-196 from the National Institute of Allergy and Infectious Diseases and Contract No. DA-49-193-MD-2113 from the Department of the Army, Office of the Surgeon General.

Presented in part at the annual meeting of the American Association of Immunologists: Chicago—April, 1964; Atlantic City—April, 1965.

2 Research Career Investigator (K6-A1-15,210) of National Institute of Allergy and Infectious Diseases, National Institutes of Health.

3 Present address: Department of Biochemistry, Jefferson Medical College, Philadelphia, Pennsylvania.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1966 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1966 by The American Association of Immunologists, Inc. All rights reserved.