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Lymphocytopoiesis, Plasmacytopoiesis and Cellular Proliferation in Nonantigenically Stimulated Germfree Mice¹

From the Lobund Laboratory, University of Notre Dame, Notre Dame, Indiana

Abstract

Quantitative evaluation of lymphocytopoiesis and plasmacytopoiesis in various lymph nodes of germfree and conv mice show the conv animals have about 3 times (% basis) or 12 times (absolute basis determined from mesenteric lymph nodes) more blast and potential antibody producing cells than their germfree counterparts. Other cellular aspects such as cell distribution within respective lymph nodes and proliferation rate of lymphoid cells are not affected by the animal's germfree status.

Two hours after tritiated thymidine (TH³) pulse labelling, the nodes of the conv mice contained more labelled cells per 1000 cells than the respective nodes of germfree mice. Evidence suggests this difference was due to a smaller quantity of less differentiated cells and to a restriction of TH³ label movement in nodes of germfree mice. Cells which became labelled incorporated the TH³ to the same extent in both germfree and conv mice.

Footnotes

¹ This reasearch was supported specifically by National Institutes of Health Research Fellowship G-17, 1936, National Science Foundation Grant GB1105, and generally by the Office of Naval Research and by the University of Notre Dame.

This research was submitted in partial fulfillment of the requirements for the Doctorate of Philosophy Degree, University of Notre Dame.

² Present address: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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