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Antigens Characteristic for Amyloid of Man and Rabbit¹

From the Department of Medicine and Department of Bacteriology and Immunology, State University of New York at Buffalo, Buffalo, New York

Abstract

Rabbit antisera to human amyloid tissue gave a positive indirect immunofluorescence test with sections of amyloid-containing organs. Absorption experiments indicated that antibodies to previously described amyloid-characteristic components participated in this test.

Evidence was presented that the amyloid antigen described by Cathcart et al. is probably identical with the previously described lipoprotein component of amyloid-containing tissues.

By means of guinea pig immune sera, a lipoprotein antigen was identified in amyloid-containing rabbit organs. An identical antigen was detected in normal rabbit serum but not in normal rabbit organs.

Footnotes

¹ This investigation was supported by Research Grant AM-05581-05 and Training Grant T1 AM-5075-10 from the National Institute of Arthritis and Metabolic Diseases, United States Public Health Service.

² Fellow of the Western New York Chapter of the Arthritis and Rheumatism Foundation.