HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tokumaru, T. Search for Related Content PubMed PubMed Citation Articles by Tokumaru, T.

A Possible Role of A-Immunoglobulin in Herpes Simplex Virus Infection in Man¹

From the Children's Hospital of Philadelphia, Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

The capacities to synthesize A in normal subjects and persons with primary and recurrent herpetic infections were analyzed and compared. Complications of primary infections and recurrences appeared to be associated with a deficiency of herpes-specific A. The threshold protective titer of this A appeared to be 12 to 20. The initial immune response to herpes infection was characterized by a marked increase in the M titer, followed after 21 days by a predominance of A and G. The protective effect of A in the mucocutaneous tissues appears to be associated with its high avidity for the herpes simplex virus and its active secretion by such tissues.

Footnotes

¹ This investigation was supported by Research Grant AI-05612 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service, Bethesda, Maryland.