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Relative Antigenic Potency in Man of Polyvalent Influenza Virus Vaccines Containing Isolated Hemaggi Utinins or Intact Viruses¹

From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

The antibody responses of military recruits to vaccination with aqueous or mineral oil adjuvant polyvalent vaccines containing either purified hemagglutinins or intact viruses were compared. The yield of HI antibodies was generally higher after vaccination with purified hemagglutinins derived from swine, A, A₁ and A₂ strains than after vaccination with the corresponding intact viruses. The yield of HI antibodies after vaccination with hemagglutinins obtained from prototype strains of influenza B was always at least equal to that observed after use of intact virus vaccines, and sometimes higher. The significance of these findings is discussed.

Footnotes

¹ This investigation was conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board, and was supported by the Office of the Surgeon General, United States Army, Washington, D. C.