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The Journal of Immunology, 1966, 97: 189-196.
Copyright © 1966 by The American Association of Immunologists, Inc.
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Ontogeny of the Immune Response

II. Characterization of 19S{gamma}G- and 7S{gamma}G-Immunoglobulins in the True Primary and Secondary Responses in Piglets1

Yoon Berm Kim, S. Gaylen Bradley and Dennis W. Watson

From the Department of Microbiology, University of Minnesota, Minneapolis, Minnesota

Abstract

The ontogeny of immunoglobulin development was demonstrated in immunologically virgin piglets; the first antibody formed, as a true primary response to the specific antigenic stimulus, was 19S {gamma}G ({gamma}1)-immunoglobulin distinct from so-called beta2M ({gamma}M)-macroglobulin. The 19S {gamma}G ({gamma}1)-immunoglobulin appeared antigenically identical to the 7S {gamma}G ({gamma}2)-immunoglobulin which developed later in the piglet and was present in normal sow serum. These results indicate that immunoglobulin synthesis was initiated by specific antigenic stimuli and that there was sequential development of 19S {gamma}G ({gamma}1) to 7S {gamma}G ({gamma}2)-immunoglobulin.

It is suggested that antigen is the sole inducer of specific antibody by de novo synthesis of immunoglobulins including early 19S {gamma}G ({gamma}1) and late 7S {gamma}G ({gamma}2). These results do not support the concept, suggested in Jerne's natural selection hypothesis, that pre-existing antibody is necessary for antibody formation.

Both early true primary 19S {gamma}G ({gamma}1) and early secondary 19S {gamma}G ({gamma}1)-immunoglobulins were identical but distinct from so-called beta2M-macroglobulin and antigenically identical to 7S {gamma}G ({gamma}2)-immunoglobulins of late true primary and secondary responses.

Footnotes

1 This work was supported by United States Public Health Service Grant AI-3439-06.






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