HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Webster, R. G. Search for Related Content PubMed PubMed Citation Articles by Webster, R. G.

Original Antigenic Sin in Ferrets: the Response to Sequential Infections with Influenza Viruses¹

From the Department of Epidemiology and the Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

Infection of ferrets with influenza viruses resulted in the production of large numbers of antibody molecules of low avidity. With the passage of time the number of antibody molecules decreased while the average avidity increased. Sequential infection of ferrets with serologically related viruses caused a marked increase in the number of antibody molecules reacting with the first virus. The avidity of this antibody was similar to that of the antibody before reinfection. The antibody reacting with the second virus was of secondary quality. The antibody population 18 to 21 days after secondary infection with a related virus was heterogeneous in terms of avidity, some of the antibodies reacting with either one or the other of the infecting viruses and some reacting with both viruses.

Footnotes

¹ This investigation was conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board. The work at the University of Michigan was supported by the Office of the Surgeon General, United States Army, Washington, D.C.

² Present address: Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T., Australia.

This article has been cited by other articles:

				X. S. Liu, Y. Xu, L. Hardy, V. Khammanivong, W. Zhao, G. J. P. Fernando, G. R. Leggatt, and I. H. Frazer IL-10 Mediates Suppression of the CD8 T Cell IFN-{gamma} Response to a Novel Viral Epitope in a Primed Host J. Immunol., November 1, 2003; 171(9): 4765 - 4772. [Abstract] [Full Text] [PDF]

				R. A. K. Singh, J. R. Rodgers, and M. A. Barry The Role of T Cell Antagonism and Original Antigenic Sin in Genetic Immunization J. Immunol., December 15, 2002; 169(12): 6779 - 6786. [Abstract] [Full Text] [PDF]