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Presence of Identical Antigenic Determinants in the Fd Fragments of ₁- and ₂-Guinea Pig Immunoglobulins¹

From the Department of Pathology, New York University School of Medicine, New York, New York

Abstract

Rabbit antisera prepared against guinea pig ₂-globulin digested by pepsin react with isolated H and L chains. They contain antibodies against part of the H chain, the Fd fragment, and not against the Fc fragment. These antisera, directed against L chains and Fd fragments from ₂-globulins, do not detect any differences between ₁- and ₂- guinea pig immunoglobulins, when double diffusion in gel techniques are used. These results show that not only L chains but also Fd fragments of these different classes of immunoglobulins have common antigenic determinants.

Footnotes

¹ This study was supported by the United States Public Health Service Grants AI04983 and AI-2094, and by the Health Research Council of the City of New York under Contract I-138.

Wherever possible, a similar nomenclature to that suggested during the W.H.O. Meeting on Nomenclature of Human Immunoglobulins has been used (Bull. World Health Org., 30: 447, 1964). However, as some uncertainty remains concerning the relationship between the families of human and animal immunoglobulins, guinea pig 7S globulins have been termed ₁ and ₂ as previously suggested.

² Career Scientist of the Health Research Council of the City of New York.