HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Fox, E. N. Articles by Wittner, M. K. Search for Related Content PubMed PubMed Citation Articles by Fox, E. N. Articles by Wittner, M. K.

Antigenicity of the M Proteins of Group A Hemolytic Streptococci

II. Antibody Response in Rabbits to Vaccines Prepared with Oil Emulsions and Aluminum Hydroxide¹

From the La Rabida-University of Chicago Institute and the Department of Microbiology, The University of Chicago, Chicago, Illinois

Abstract

Highly purified M proteins have excellent antigenic capacities in rabbits when administered in the form of repository subcutaneous doses with adjuvants. Both mineral oil and peanut oil emulsions prepared with Arlacel A and as little as 10 µg of M protein, after two or three injections, stimulated type-specific protective antibodies. Small doses of M proteins adsorbed to aluminum hydroxide were equally efficacious preparations for vaccine purposes. The attributes of these immunization procedures are discussed in terms of a practical antistreptococcal vaccine for human use. The globulin nature of the antibodies induced in rabbits immunized with purified M proteins or whole bacterial cells was also investigated. Both types of antigenic stimulation induced IgG antibodies but with different precipitating and hemagglutinating capacities.

Footnotes

¹ This work was supported by grants AI-04342 and AI-05996 from the National Institutes of Health and from The National Foundation.