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Serum Effect on the Killing of Staphylococcus Aureus by Human Leukocytic Extracts¹

From the Department of Public Health and Preventive Medicine, School of Medicine, University of Pennsylvania, the Department of Clinical Pathology of the Philadelphia General Hospital, and the United States Veterans Administration Hospital, Philadelphia, Pennsylvania

Abstract

The killing phenomenon of Staphylococcus aureus by human blood leukocytes is reconstituted extracellularly. The greatest killing action is manifested with the extract of the lysosomal granules of the leukocyte lysate around pH 5.0. Humoral factors as provided by the serum of healthy human adults significantly increase the rate of killing of the staphylococci. The effectiveness of human serum in preparing the bacteria for extracellular bactericidal action is considerably reduced by heating at 56°C, by adsorption with aggregated human -globulin or by the addition of ethylenediaminetetracetic acid in the serum.

Footnotes

¹ This work was aided by Grant A1 05473 from the National Institutes of Health and by the United States Veterans Administration Central Office Research Service.

² Fellow of the Theresa F. and Joseph Felsen Memorial Fund.