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The Nature of an Antigenic Determinant¹

From the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York, New York

Abstract

Immunochemistry has sought for many years to understand the exact chemical nature of an antigenic determinant and to know how it reacts with the extraordinarily complex and heterogeneous population of immunoglobulin molecules that possess regions complementary to it, e.g., antibody combining sites.

Footnotes

¹ Work of the laboratory is supported by the National Science Foundation and the Office of Naval Research and the General Research Support Grant of the United States Public Health Service.

Presidential address delivered before the American Association of Immunologists, April 13, 1966.

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