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Tolerance to Bovine -Globulin in Adult Guinea Pigs¹

From the Division of Allergy and Immunology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

Pretreatment of adult guinea pigs by the intravenous administration of antigen (bovine -globulin) renders a high propertion of animals tolerant to the antigen after injection of antigen in complete Freund's adjuvant, as evidenced by failure to display delayed skin reactivity at sites of subsequent intracutaneous inoculation of antigen. That these animals have, indeed, responded to the antigen immunologically is shown by the presence of sufficient antibody to demonstrate active cutaneous anaphylaxis. In addition, labeled antigen (I¹²⁵ or fluorescein) is handled differently in lymph nodes and splenic tissue of the tolerant animals than in either normal control animals or animals specifically sensitized to BGG in the classical manner. This suggests that the state of tolerance induced is an active one, requiring host discrimination and participation.

Footnotes

¹ This work was made possible by the generous support of the Ship 'N Shore Fund and by USPHS Postdoctoral Fellowship #5F2 HD-20,472-02 (to J. W. S.) from the Institute of Child Health and Human Development.

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