HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Underwood, G. E. Articles by Weed, S. D. Search for Related Content PubMed PubMed Citation Articles by Underwood, G. E. Articles by Weed, S. D.

Protective Effect of Elevated Temperature on Mice Infected with Coe Virus

From The Upjohn Company, Kalamazoo, Michigan

Abstract

Mice infected with Coe virus and held at 36°C had many more survivors than those held at 25°C. Relatively little virus was recovered from muscle of those kept at the higher temperature. Infected mice held up to 3 days at 25°C, then put at 36°C, were protected, even though much virus multiplication had occurred.

Mice inoculated with Coe virus and challenged 1 to 4 days later were more resistant to Coe challenge than were those which had not received the initial inoculum. This resistance was enhanced by holding the animals at 36°C rather than 25°C during the interval between initial and challenge inocula. Those inoculated with Coe virus showed no resistance to herpes challenge.

Coe-infected mice treated with thio-TEPA, a known immunosuppressant, were not protected by being held at 36°C, suggesting that the protective effect of elevated temperature was due, in part, to stimulated production of specific antibody.