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Enhanced Immunologic Sensitization of Mice by the Simultaneous Injection of Antigen and Specific Antiserum¹

II. Effect of Varying the Antigen-Antibody Ratio and the Amount of Immune Complex Injected

From the Physiology Department, Stanford University, Stanford, California

Abstract

1. An enhanced immune response to bovine serum albumin (BSA) was elicited only following the injection of complexes formed in antigen excess.

2. The enhanced response to BSA was biphasic; the first peak was dose-dependent, while the second peak was dose-independent.

3. The antigen-antibody ratio is more important in eliciting an enhanced response than the amount of antigen injected.

4. Using the same amount of antigen, immune complexes are much more effective than alum precipitated antigen.

5. An enhanced response to rabbit -globulin (RGG) was also elicited using immune complexes. The magnitude of the response was relatively independent of the antigen-antibody ratio and it exhibited a single peak at about 7 to 8 weeks.

6. The responses to RGG and BSA appeared to be noncompetitive.

Footnotes

¹ This work was supported by Grant E-3733 from the United States Public Health Service.

² National Science Foundation Predoctoral Fellow.

³ United States Public Health Service Career Development Awardee GM-K3-5794-C6.